Brain MRI evolution of metronidazole intoxication.

A 64-year-old woman presented with a 6-month history of intermittent episodes of ataxia and dysarthria. She had been on metronidazole 1,500 mg daily for ulcerative colitis for 10 months. Cranial MRI 3 months before admission revealed hyperintensity in corpus callosum and bilateral dentate nuclei (figure 1, A–C). MRI on admission revealed cystic necrotic degeneration (figure 1, D and E) and cytotoxic edema (figure 2) in corpus Figure 1 Consecutive MRI in a patient with metronidazole intoxication